FEBS Journal highly cited papers

Top cited FEBS Journal papers two years from publication (for publication period Oct 07 - Mar 08)

Active-site-specific chaperone therapy for Fabry disease : Yin and Yang of enzyme inhibitors
Jian-Qiang Fan, Satoshi Ishii
FEBS Journal 274, 4962-4971, October 2007

Dr Jian-Qiang Fan received his PhD degree from Kyoto University, Japan, and conducted postdoctoral research at the Johns Hopkins University. He joined Mount Sinai School of Medicine as a faculty member in 1999, and proposed and developed the pharmacological chaperone therapy for treating lysosomal storage disorders. The drug discovered in his lab for treating Fabry disease is now under clinical phase III trial. He is the Scientific Founder of Amicus Therapeutics, Inc. (Cranbury, NJ, USA).

Substrate recognition by the protein disulfide isomerases
Feras Hatahet, Lloyd W. Ruddock
FEBS Journal 274, 5223-5234, October 2007

Feras Hatahet received a BSc degree in Chemistry from Damascus University in 2002 and an MSc degree in Biotechnology from the University of Manchester in 2004. Subsequently, he spent 6 months at the Department of Biochemistry and Biophysics, Stockholm University. Currently he is a PhD candidate at the Department of Biochemistry, University of Oulu, Finland. His research focuses on the development of novel methodologies of disulphide bond formation in the cytoplasm of E.coli.

Active Υ-secretase is localized to detergent-resistant membranes in human brain
Ji-Yeun Hur, Hedvig Welander, Homira Behbahani, Mikio Aoki, Jenny Frånberg, Bengt Winblad, Susanne Frykman, Lars O. Tjernberg
FEBS Journal 275, 1174-1187, March 2008

Ji-Yeun Hur is a PhD student at the KI-Alzheimer’s Disease Research Center, Dept. of NVS, Karolinska Institutet, Stockholm, Sweden. Her research is focused on the subcellular localization of the Alzheimer’s disease related Υ-secretase complex, and to discover novel interacting proteins that affect its activity. She defends her thesis in May 2010.

Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics
Fred W. McLafferty, Kathrin Breuker, Mi Jin, Xuemei Han, Giuseppe Infusini, Honghai Jiang, Xianglei Kong, Tadhg P. Begley
FEBS Journal 274, 6256-6268, December 2007

Fred W. McLafferty (Peter J. W. Debye Professor of Chemistry, Cornell University) is a mass spectrometry pioneer in gaseous ion reactions, instrumentation, proteomics, computerization, and reference spectra collection. He is a member of the National Academy of Sciences and American Academy of Arts and Sciences, and has published over 500 papers.

Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library
Jeannine Mohrlüder, Thomas Stangler, Yvonne Hoffmann, Katja Wiesehan, Anja Mataruga, Dieter Willbold
FEBS Journal 274, 5543-5555, November 2007

Dr Jeannine Mohrlüder is a scientist at the Institute of Structural Biology and Biophysics of the Research Centre Jülich in Germany. Her current work focuses on the identification and characterization of protein-protein interactions of the human GABA type A receptor associated protein GABARAP. She majored in Biology at the Johannes Gutenberg University in Mainz, Germany and the University of Montpellier II in France, and carried out her diploma thesis at the Institute of Biochemistry of the University of Cologne in Germany.
She did her PhD at the Heinrich-Heine-University of Düsseldorf, Germany.

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease
Rafael Pulido, Rob Hooft van Huijsduijnen
FEBS Journal 275, 848-866, March 2008

Rafael Pulido is the Head of Molecular Biology of Cancer Laboratory at Centro de Investigación Príncipe Felipe, Valencia, Spain. His work is focused on the role of protein phosphatases and kinases in cancer.

Rob Hooft van Huijsduijnen is Associate Director Molecular Neurobiology at Merck Serono, Geneva, Switzerland. He is responsible for Molecular Biology support in the Neurodegenerative Diseases Therapeutic Area, particularly Multiple Sclerosis, aimed at discovering new clinical therapies.

RP and RHH belong to PTPNET, an FP6 Research Training Network: Protein tyrosine phosphatases: structure, regulation and biological function (www.ptpnet.ich.ucl.ac.uk). The awarded review forms part of a minireview series on PTPs contributed by PTPNET (FEBS J. 275, 815, March 2008).

Photosynthetic acclimation: Does the dynamic structure and macro-organisation of photosystem II in higher plant grana membranes regulate light harvesting states?
Peter Horton, Matthew P. Johnson, Maria L. Perez-Bueno, Anett Z. Kiss, Alexander V. Ruban
FEBS Journal 275, 1069-1079, March 2008

Amyloid–cholinesterase interactions : Implications for Alzheimer's disease
Nibaldo C. Inestrosa, Margarita C. Dinamarca, Alejandra Alvarez
FEBS Journal 274, 625-623, February 2008

Protein lipidation
Marissa J. Nadolski, Maurine E. Linder
FEBS Journal 274, 5202-5210, October 2007

Protein tyrosine phosphatases: structure–function relationships
Lydia Tabernero, A. Radu Aricescu, E. Yvonne Jones, Stefan E. Szedlacsek
FEBS Journal 275, 867-882, March 2008

Pharmacologic chaperoning as a strategy to treat Gaucher disease
Zhanqian Yu, Anu R. Sawkar, Jeffery W. Kelly
FEBS Journal 274, 4944-4950, October 2007